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May 1, 1996Journal of Biological ChemistryOpen Access

Systematic Replacement of Amino Acid Residues within an Arg-Gly-Asp-containing Loop of Foot-and-Mouth Disease Virus and Effect on Cell Recognition

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Population

Susceptible cells infected with foot-and-mouth disease virus (FMDV) isolate C-S8c1

Design

Preclinical

Authors

MMMauricio G. MateuCentro de Biología Molecular Severo OchoaMVM. Luz ValeroUniversitat de ValènciaDADavid AndreuRutgers, The State University of New Jersey

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Implication

May guide FMDV entry inhibitor design; leaves open human translation from animal cell data.

Structured PICO

P
Population
Susceptible cells infected with foot-and-mouth disease virus (FMDV) isolate C-S8c1
I
Intervention
241 synthesized 15-mer peptides representing the RGD-containing loop of FMDV and single variants
O
Outcome
Inhibitory activity of peptides on the ability of FMDV C-S8c1 to recognize and infect susceptible cellssurrogate

The study identifies specific amino acid residues downstream of the RGD motif in FMDV that are critical for viral cell recognition.

Cite This Study

Mateu et al. (1996) studied this question.

synapsesocial.com/papers/6a9232b335ce4f6d11675d64https://doi.org/10.1074/jbc.271.22.12814
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of substituted and tandem‐repeated peptides to probe the relevance of the highly conserved RGD tripeptide in the immune response against foot‐and‐mouth disease virus1993 · 34 citations
  2. 2The nucleotide sequences of wild-type coxsackievirus A9 strains imply that an RGD motif in VP1 is functionally significant1992 · 64 citations
  3. 3Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection1993 · 121 citations
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  5. 5Genome variation in the SAT types of foot-and-mouth disease viruses prevalent in buffalo (<i>Syncerus caffer</i>) in the Kruger National Park and other regions of southern Africa, 1986–931995 · 51 citations