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September 20, 1993FEBS Letters

Use of substituted and tandem‐repeated peptides to probe the relevance of the highly conserved RGD tripeptide in the immune response against foot‐and‐mouth disease virus

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Population

Rabbits, guinea pigs, and synthetic peptides representing site A of foot-and-mouth disease virus (FMDV)

Design

Preclinical

Authors

INIsabel S. NovellaUniversity of Toledo Medical CenterBBBelén BorregoInstituto Nacional de Investigación y Tecnología Agraria y AlimentariaMMMauricio G. MateuCentro de Biología Molecular Severo Ochoa

Discussion

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Implication

RGD residues define key FMDV epitopes; leaves open whether tandem repeats can yield durable, high-titer vaccines in animals.

Structured PICO

P
Population
Rabbits, guinea pigs, and synthetic peptides representing site A of foot-and-mouth disease virus (FMDV)
I
Intervention
Substituted peptides and tandem repeats of the RGDL sequence (corresponding to FMDV C-S8c1)
O
Outcome
Reactivity of substituted peptides with site A-specific monoclonal antibodies and ability to evoke neutralizing antibodiessurrogate

The RGD tripeptide is involved in the antigenic structure of FMDV site A, and tandem repeats of this domain can induce broadly neutralizing antibodies, though activity decreases with boosting.

Cite This Study

Novella et al. (1993) studied this question.

synapsesocial.com/papers/6a92691efd48e269e6b898cbhttps://doi.org/10.1016/0014-5793(93)80883-v
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Cell Attachment Site on Foot-and-Mouth Disease Virus Includes the Amino Acid Sequence RGD (Arginine-Glycine-Aspartic Acid)1989 · 388 citations
  2. 2Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.1989 · 124 citations
  3. 3Antigenic sites on foot-and-mouth disease virus type A101988 · 179 citations
  4. 4Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus1990 · 41 citations
  5. 5Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination1987 · 280 citations