What does this research mean for the field?

Replacing the RGD integrin-recognition motif with RGG in the foot-and-mouth disease virus (FMDV) capsid protein VP1 causes significant antigenic variations and validates the critical role of Asp-143 in antibody recognition, while demonstrating that such mutants can remain genetically stable and expand the virus's antigenic sequence repertoire. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

August 1, 1999Journal of General Virology

Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif

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Population

Foot-and-mouth disease virus (FMDV) clone C-S8c1 and BHK-21 cells

Comparison

FMDV clone with an Arg-Gly-Gly triplet instead… vs Parental FMDV clone C-S8c1 with RGD motif

Design

Preclinical

Authors

CRCarmen M. Ruiz-JaraboConsejo Superior de Investigaciones Científicas NSNoemı́ SevillaConsejo Superior de Investigaciones Científicas MDMercedes DávilaCentro de Biología Molecular Severo Ochoa

Discussion

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Implication

May inform FMDV vaccine updates; supports consensus on capsid roles yet leaves open natural-host stability.

Structured PICO

Population

Foot-and-mouth disease virus (FMDV) clone C-S8c1 and BHK-21 cells

Intervention

FMDV clone with an Arg-Gly-Gly (RGG) triplet instead of the Arg-Gly-Asp (RGD) integrin-recognition motif at positions 141 to 143 of capsid protein VP1

Comparator

Parental FMDV clone C-S8c1 with RGD motif

Outcome

Antigenic differences and genetic stability during serial infectionssurrogate

Replacements at critical capsid sites involved in receptor recognition can prompt large antigenic variations while maintaining viral stability to replicate efficiently.

Cite This Study

Ruiz-Jarabo et al. (1999) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57d7 https://doi.org/10.1099/0022-1317-80-8-1899

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Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider