Key result
Both SGD- and RGD-containing FMDV A24 viruses were highly virulent in cattle, causing rapid onset of clinical disease and transmitting to in-contact animals.
Population
In vitro (BHK-21 cells, BHK3-alphabeta cells) and in vivo models for Foot-and-mouth disease virus type A…
Comparison
FMDV mutant clones containing an SGD sequence in… vs Revertant RGD viruses or original RGD-containing…
Design
Preclinical
Authors
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SGD-FMDV virulence in cattle warrants variant surveillance; leaves open whether alternative integrin motifs drive outbreaks or vaccine failure.
FMDV can evolve to use sequences other than RGD (such as SGD) to infect via integrin receptors and induce disease in susceptible animals.
Rieder et al. (2005) studied Foot-and-mouth disease (n=4). FMDV A24-SGD virus vs. FMDV A24-RGD virus was evaluated on Clinical manifestations of FMD and viremia. Both SGD- and RGD-containing FMDV A24 viruses were highly virulent in cattle, causing rapid onset of clinical disease and transmitting to in-contact animals.
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