Why the study?
Does the use of antiplatelet drugs increase the risk of upper gastrointestinal bleeding, and do proton pump inhibitors prevent it in adults?
Does the use of antiplatelet drugs increase the risk of upper gastrointestinal bleeding, and do proton pump inhibitors prevent it in adults?
Concomitant use of proton pump inhibitors substantially decreases the risk of upper gastrointestinal bleeding associated with antiplatelet drugs, making acetylsalicylic acid plus a PPI potentially safer than ticlopidine or clopidogrel alone.
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PPI co-prescription may attenuate acetylsalicylic acid-associated upper GI bleeding risk; leaves open confirmation of net benefit in randomized trials.
Ibáñez et al. (2005) studied this question.
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