September 1, 2010Nephron Experimental Nephrology

High Glucose Upregulates Upstream Stimulatory Factor 2 in Human Renal Proximal Tubular Cells through Angiotensin II-Dependent Activation of CREB

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Structured PICO

Population

Human renal proximal tubular cells (HK-2 cells)

Intervention

High-glucose medium (with or without siRNA-mediated USF2 knockdown or losartan)

Comparator

Normal-glucose medium

Outcome

USF2 expression and extracellular matrix accumulationsurrogate

Discussion

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Implication

High glucose stimulates USF2 expression in human renal proximal tubular cells via an angiotensin II-AT1-dependent activation of CREB, contributing to diabetic tubulointerstitial fibrosis.

Cite This Study

Visavadiya et al. (2010) studied this question.

synapsesocial.com/papers/6a924be6ce96c166766c4e34 https://doi.org/10.1159/000320593

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Implication

High glucose stimulates USF2 expression in human renal proximal tubular cells via an angiotensin II-AT1-dependent activation of CREB, contributing to diabetic tubulointerstitial fibrosis.

High Glucose Upregulates Upstream Stimulatory Factor 2 in Human Renal Proximal Tubular Cells through Angiotensin II-Dependent Activation of CREB

Structured PICO

Discussion

Implication

Cite This Study

High Glucose Upregulates Upstream Stimulatory Factor 2 in Human Renal Proximal Tubular Cells through Angiotensin II-Dependent Activation of CREB

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider