Does Nitric Oxide Regulate Skeletal Muscle Glucose Uptake during Exercise?

In Brief Although rodent studies are contradictory, there is accumulating evidence in humans suggesting that nitric oxide (NO) is involved in skeletal muscle glucose uptake during exercise. This brief review discusses this controversial area, including potential upstream regulators of skeletal muscle NO synthase (NOS). Whereas rodent studies are contradictory, there is accumulating evidence in humans suggesting that nitric oxide is involved in skeletal muscle glucose uptake during exercise.