Why the study?
Suxamethonium-induced fasciculation and post-operative myalgia are known side effects following suxamethonium administration, but their incidence, severity, and association with different IV induction agents needed evaluation.
Do different IV induction agents (propofol, thiopentone, ketamine, ketofol) affect the incidence and severity of suxamethonium-induced fasciculation and post-operative myalgia in adult patients undergoing elective surgery?
Population
140 adult patients undergoing elective surgery at Jimma Medical Center
Comparison
Four IV induction agents: propofol vs thiopentone vs ketamine vs ketofol
Design
Prospective cohort study
Authors
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SIF/POM incidence high irrespective of induction agent; leaves open whether agent selection mitigates effects in larger trials.
Do different IV induction agents (propofol, thiopentone, ketamine, ketofol) affect the incidence and severity of suxamethonium-induced fasciculation and post-operative myalgia in adult patients undergoing elective surgery?
Different IV induction agents (propofol, thiopentone, ketamine, ketofol) do not significantly alter the high incidence of suxamethonium-induced fasciculation and post-operative myalgia.
Wondu Reta Demissie (2021) studied this question.
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