What question did this study set out to answer?

Assess the feasibility and analytical performance of an implantable subcutaneous glucose sensor equipped with bioprotective membranes over extended periods in a canine model.

August 1, 1994Diabetes Care

Evaluation of a Subcutaneous Glucose Sensor out to 3 Months in a Dog Model

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Authors

BGBarbara GilliganGuy's Hospital MSM C ShultsUniversity of Wisconsin–Madison RRRathbun K. RhodesUniversity of Wisconsin–Madison

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Implication

Preclinical study demonstrates continuous glucose tracking for up to 114 days in canines, indicating bioprotective membrane stability limits long-term sensor function.

Key Points

Assess the feasibility and analytical performance of an implantable subcutaneous glucose sensor equipped with bioprotective membranes over extended periods in a canine model.
Constructed sensors with one of eight bioprotective membranes and implanted them subcutaneously into nondiabetic mongrel dogs, collecting data at 4-minute intervals via radiotelemetry.
Evaluated sensor tracking using glucagon challenges and 25 separate intravenous glucose infusion studies following octreotide inhibition of endogenous insulin, referencing blood glucose every 4 to 10 minutes.
Ten implanted sensors tracked glucose from 20 to 114 days, yielding a mean regression slope of 0.99 ± 0.06, an intercept of 0.24 ± 0.53 mM glucose, and a correlation coefficient of 0.98 ± 0.01.
Two of eight bioprotective membranes maintained biostability and protected the enzyme layer, with two sensors tracking within ±15% of reference values for 33 and 42 days.
Sensor systems ultimately failed due to electronic packaging leakage, in vivo oxygen delivery constraints, or membrane biofouling and biodegradation.

Cite This Study

Gilligan et al. (1994) studied this question.

synapsesocial.com/papers/6a92604d976eaf2834c8029f https://doi.org/10.2337/diacare.17.8.882

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Implication

Preclinical study demonstrates continuous glucose tracking for up to 114 days in canines, indicating bioprotective membrane stability limits long-term sensor function.

Evaluation of a Subcutaneous Glucose Sensor out to 3 Months in a Dog Model

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Implication

Key Points

Cite This Study

Evaluation of a Subcutaneous Glucose Sensor out to 3 Months in a Dog Model

Discussion

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Implication

Key Points

Cite This Study

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