August 10, 2010Hypertension

Moment-to-Moment Characteristics of the Relationship Between Arterial Pressure and Renal Interstitial Hydrostatic Pressure

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Population

Wistar rats

Comparison

Hexamethonium or losartan vs No treatment

Design

Preclinical

Authors

MKMarina KomolovaQueen's University MAMichael A. AdamsLawrence Berkeley National Laboratory

Discussion

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Implication

Should not change hypertension care; leaves open whether rapid RIHP coupling modulates sodium excretion in humans.

Structured PICO

Population

Wistar rats

Intervention

Hexamethonium (20 mg/kg per hour IV) or losartan (10 mg/kg per hour IV)

Comparator

No treatment

Outcome

Changes in renal interstitial hydrostatic pressure (RIHP) over a range of renal arterial pressuressurrogate

Spontaneous changes in arterial pressure are rapidly coupled to changes in renal interstitial hydrostatic pressure, highlighting a dynamic component in the modulation of sodium excretion and arterial pressure.

Cite This Study

Komolova et al. (2010) studied this question.

synapsesocial.com/papers/6a92672efd48e269e6b8982e https://doi.org/10.1161/hypertensionaha.109.149633

View Full Paper

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Bookmark

Moment-to-Moment Characteristics of the Relationship Between Arterial Pressure and Renal Interstitial Hydrostatic Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Moment-to-Moment Characteristics of the Relationship Between Arterial Pressure and Renal Interstitial Hydrostatic Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider