Population
Pre- and postimplantation mouse embryos (in situ and in vitro)
Design
Preclinical
Authors
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May implicate trophoblast-derived NO in murine implantation angiogenesis; leaves open relevance to human pregnancy vascular adaptation.
The study demonstrates that the implanting mouse trophoblast produces nitric oxide via eNOS and iNOS, which may participate in local vasodilatation and angiogenesis during pregnancy.
Gagioti et al. (2000) studied this question.
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