Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 11, 2005Cardiovascular ResearchOpen Access

Renovascular effects of sympathetic cotransmitters ATP and NPY are age-dependent in spontaneoulsy hypertensive rats

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated perfused kidneys of young and adult spontaneously hypertensive and normotensive rats

Comparison

Renal nerve stimulation and pharmacological agents vs Normotensive WKY rats and young SH-SP rats

Design

Preclinical

Authors

OVOliver VonendDeutsche Post (Germany)AOAnna OkonekJSJohannes StegbauerDüsseldorf University Hospital

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for adaptive loss of NPY Y1 modulation in hypertensive aging; human validation required before clinical relevance.

Structured PICO

P
Population
Isolated perfused kidneys of young (8-10 weeks) and adult (18-24 weeks) spontaneously hypertensive (SH-SP) and normotensive (WKY) rats
I
Intervention
Renal nerve stimulation (RNS) and pharmacological agents (phentolamine, suramin, BIBP3226, NPY, norepinephrine, alpha,beta-mATP)
C
Comparator
Normotensive WKY rats and young SH-SP rats
O
Outcome
Pressor responses to renal nerve stimulations (RNS) and drugssurrogate

Aging in spontaneously hypertensive rats is associated with a loss of the modulatory role of renal NPY Y1 receptors, which may be an adaptive mechanism to heightened pressor responses to norepinephrine and ATP.

Cite This Study

Vonend et al. (2005) studied this question.

synapsesocial.com/papers/6a92746f2f423575984656d0https://doi.org/10.1016/j.cardiores.2004.12.005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low concentrations of angiotensin II unmask vasoconstrictory 2-adrenoceptors in isolated perfused kidneys of spontaneously hypertensive rats1995 · 13 citations
  2. 2Increased Sympathetic Nerve Activity in Renovascular Hypertension1999 · 173 citations
  3. 3Vascular Structural and Functional Alterations Before and After the Development of Hypertension in SHR1994 · 101 citations
  4. 4Noradrenaline Release and the Pathophysiology of Primary Human Hypertension1989 · 139 citations
  5. 5Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat2004 · 27 citations