December 4, 2006Hypertension

Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy

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Population

Rat model of experimental renal failure and cultured isolated cardiac fibroblasts

Comparison

Marinobufagenin infusion, 5/6th nephrectomy… vs PNx alone; untreated fibroblasts

Design

Preclinical

Authors

JEJihad ElkarehNational Institute on Aging DKDavid J. KennedyUniversity of Toledo BYBelvadi YashaswiNational Institute on Aging

Discussion

Member takes

Implication

May mediate cardiac fibrosis in experimental uremia; hypothesis-generating for MBG-targeted therapies in patients.

Structured PICO

Population

Rat model of experimental renal failure (5/6th nephrectomy model, PNx) and cultured isolated cardiac fibroblasts

Intervention

Marinobufagenin (MBG) infusion, 5/6th nephrectomy (PNx) after immunization against MBG, concomitant PNx and adrenalectomy; in vitro MBG at 1 nM concentration

Comparator

PNx alone (for in vivo studies); untreated fibroblasts (for in vitro studies)

Outcome

Cardiac fibrosis and procollagen-1 expressionsurrogate

Marinobufagenin directly stimulates collagen expression by cardiac fibroblasts, contributing to cardiac fibrosis and diastolic dysfunction in experimental uremic cardiomyopathy.

Cite This Study

Elkareh et al. (2006) studied this question.

synapsesocial.com/papers/6a92747d64e69d4ef346574d https://doi.org/10.1161/01.hyp.0000252409.36927.05

Topics

Cardiomyopathy

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Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider