Design, synthesis, antibacterial, and antifungal studies of novel 3-substituted coumarinyl-triazine derivatives

A series of novel 3-substituted coumarinyl-triazine derivatives were designed and synthesized from 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water. All synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, MS, and elemental analysis. Further, in vitro screening was carried out against four bacterial strains ( Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Salmonella typhi ) and two fungal strains ( Aspergillus niger and Aspergillus clavatus ).