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April 1, 1972The Anatomical Record

Filamentous and matrix components of skeletal muscle Z‐disks

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Population

Adult frog and young newt "fast" skeletal muscle

Comparison

Different aldehyde and osmium fixation… vs Comparison between collidine-buffered osmium and…

Design

Preclinical

Authors

DKDouglas E. KellyUniversity of Southern CaliforniaMCMary Ann CahillBellarmine University

Discussion

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Overview

Fixation artifacts may underlie Z-disk matrix variability in amphibians; leaves open relevance to cardiac sarcomere ultrastructure.

Structured PICO

P
Population
Adult frog and young newt "fast" skeletal muscle
I
Intervention
Different aldehyde and osmium fixation procedures, plastic section digestion techniques utilizing Pronase or pepsin, under various degrees of stretch
C
Comparator
Comparison between collidine-buffered osmium and veronal acetate-buffered glutaraldehyde fixation
O
Outcome
Structural appearance of Z-disk lattices (filamentous lattice and Z-disk matrix)surrogate

The varying images of Z-disks observed under different fixation conditions are likely due to the variable retention of the Z-disk matrix, while the filamentous lattice remains relatively stable.

Cite This Study

Kelly et al. (1972) studied this question.

synapsesocial.com/papers/6a9285c5fa60aefc093ab000https://doi.org/10.1002/ar.1091720403
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OBSERVATIONS ON ORGANIZATION OF Z-DISK COMPONENTS AND ON ROD-BODIES OF Z-DISK ORIGIN1971 · 40 citations
  2. 2The influence of fixation upon the fine structure of the z-disk of rat striated muscle1970 · 69 citations
  3. 3Myofibrillogenesis and Z‐band differentiation1969 · 130 citations
  4. 4THE EFFECT OF VARIOUS PROTEIN FRACTIONS ON Z- AND M-LINE RECONSTITUTION1969 · 73 citations
  5. 5ULTRASTRUCTURE OF THE Z LINE OF SKELETAL MUSCLE FIBERS1971 · 46 citations