Why the study?
Does RuBPY reduce arterial pressure and induce vascular relaxation compared to SNP in hypertensive and normotensive rats?
Does RuBPY reduce arterial pressure and induce vascular relaxation compared to SNP in hypertensive and normotensive rats?
RuBPY demonstrates potential advantages over SNP as a nitric oxide donor by providing a slow, long-lasting hypotensive effect without reflex tachycardia in rat models.
May support RuBPY as a long-acting NO donor in hypertension models; leaves open clinical translation pending human trials.
in its molecule. The aim of the present study was to evaluate the effect of RuBPY on arterial pressure, as well as on the vascular relaxation of different vascular arteries in renal hypertensive (2K-1C) and normotensive (2K) rats. We have evaluated the arterial pressure and heart rate changes as well as the RuBPY and SNP-induced relaxation (thoracic aorta, mesenteric resistance, coronary and basilar arteries). The administration of RuBPY in awake rats evoked a smaller but long lasting hypotensive effect when compared to SNP, with no increase in heart rate. The relaxation induced by RuBPY was similar between 2K-1C and 2K rats in thoracic aorta, mesenteric resistance and coronary arteries. However, the relaxation induced by RuBPY was smaller in basilar arteries from 2K-1C than in 2K. Taken together, our results show that RuBPY presents several advantages over SNP, since it does not induce hypotensive effect in normotensive animals, the hypotensive effect is slower, with no reflex tachycardia, and it is long lasting. In addition, RuBPY induces coronary artery relaxation (useful for angina) and presented only a small effect on basilar artery (may not induce headache).
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Pereira et al. (2016) studied this question.
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