Population
Anaesthetized and ganglion-blocked 6 week old and 20 week old spontaneously hypertensive rats and…
Comparison
Sodium nitroprusside and Nomega-nitro-L-arginine… vs Age-matched normotensive Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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Does not inform human hypertension management; leaves open whether greater NO dependency in SHR models extends to clinical disease.
Spontaneously hypertensive rats exhibit a greater tonic release of nitric oxide and higher dependency on it for blood pressure control compared to normotensive rats.
Akiba et al. (1995) studied this question.
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