Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra‐fast activating K+ currents in murine portal vein myocytes

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Acutely dispersed single smooth muscle cells from the murine portal vein or human embryonic kidney cells

Intervention

Pharmacological agents (4-aminopyridine, flecainide, phrixotoxin II) and molecular tools (RT-PCR, immunocytochemistry)

Outcome

Molecular identity and pharmacological profile of the transient K+ current (IUF)surrogate

Pharmacological and molecular evidence implicates Kv4.3 as a major component of the ultra-fast activating K+ current in murine portal vein myocytes.

No takes yet. Share an insight, caveat, or question.

Kv4.3 likely mediates IUF in murine portal vein; leaves open translation to human vascular physiology or therapy.

Yeung et al. (2006) studied this question.

View Full Paper

Ask AI

Bookmark