What does this research mean for the field?

Complete blood count-derived indices, particularly mean platelet volume, demonstrate consistent longitudinal changes during a gluten-free diet and can serve as a low-cost adjunct for monitoring dietary adherence in children with celiac disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether routine complete blood count (CBC)–derived indices can serve as low-cost markers for monitoring adherence to a gluten-free diet in pediatric celiac disease.

August 29, 2026Scientific ReportsOpen Access

Complete blood count derived indices for dietary follow up in children with celiac disease

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Authors

SSSemih SandalMinistry of Health SÇSıla Çamur AMAndrea MasottiBambino Gesù Children's Hospital

Discussion

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Implication

Retrospective cohort study reveals routine complete blood count indices track gluten-free diet adherence in pediatric celiac disease, highlighting a low-cost alternative for monitoring.

Key Points

To evaluate whether routine complete blood count (CBC)–derived indices can serve as low-cost markers for monitoring adherence to a gluten-free diet in pediatric celiac disease.
Multicenter retrospective longitudinal cohort study evaluating 163 children with celiac disease at diagnosis and after 12 months on a gluten-free diet alongside 187 age-matched control subjects with functional constipation.
Assessed complete blood count indices—mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and red cell distribution width–to–platelet ratio (RPR)—correlated with tissue transglutaminase antibody (tTG) levels using receiver operating characteristic (ROC) analyses.
At diagnosis, children with celiac disease exhibited lower MPV and higher PLR than controls (P < 0.05); after 12 months of gluten-free diet adherence, MPV and RPR significantly increased while PLR decreased (all P < 0.01).
ROC analysis identified MPV as the top individual index (AUC 0.73), where a cut-off of < 9.3 fL yielded 100% specificity and 48% sensitivity for detecting serological positivity.

Cite This Study

Sandal et al. (2026) studied this question.

synapsesocial.com/papers/6a9299088e5d7d1fc0c10cb8 https://doi.org/10.1038/s41598-026-67998-6

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August 29, 2026Scientific ReportsOpen Access

Complete blood count derived indices for dietary follow up in children with celiac disease

View Full Paper

Ask AI

Bookmark

Authors

SSSemih SandalMinistry of Health SÇSıla Çamur AMAndrea MasottiBambino Gesù Children's Hospital

Discussion

Member takes

Implication

Retrospective cohort study reveals routine complete blood count indices track gluten-free diet adherence in pediatric celiac disease, highlighting a low-cost alternative for monitoring.

Key Points

To evaluate whether routine complete blood count (CBC)–derived indices can serve as low-cost markers for monitoring adherence to a gluten-free diet in pediatric celiac disease.
Multicenter retrospective longitudinal cohort study evaluating 163 children with celiac disease at diagnosis and after 12 months on a gluten-free diet alongside 187 age-matched control subjects with functional constipation.
Assessed complete blood count indices—mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and red cell distribution width–to–platelet ratio (RPR)—correlated with tissue transglutaminase antibody (tTG) levels using receiver operating characteristic (ROC) analyses.
At diagnosis, children with celiac disease exhibited lower MPV and higher PLR than controls (P < 0.05); after 12 months of gluten-free diet adherence, MPV and RPR significantly increased while PLR decreased (all P < 0.01).
ROC analysis identified MPV as the top individual index (AUC 0.73), where a cut-off of < 9.3 fL yielded 100% specificity and 48% sensitivity for detecting serological positivity.

Cite This Study

Sandal et al. (2026) studied this question.

synapsesocial.com/papers/6a9299088e5d7d1fc0c10cb8 https://doi.org/10.1038/s41598-026-67998-6

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