What does this research mean for the field?

Proactive, pre-examination pharmacist interventions significantly improve the resolution rates of chemotherapy-related adverse events compared to conventional post-examination interventions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether proactive pharmacist interventions conducted before oncology examinations improve symptom resolution and adverse event management compared to conventional post-examination interventions.

August 29, 2026Journal of Pharmaceutical Health Care and SciencesOpen Access

Impact of interventions for adverse events by oncology pharmacists before versus after medical examination in outpatient chemotherapy: a retrospective, comparative study

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Authors

SWShinsaku WashinosuNihon University Itabashi Hospital THTatsuya HayamaNihon University Itabashi Hospital AUAkihiro UchiikeNihon University Itabashi Hospital

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Implication

Retrospective comparative study reveals higher adverse event resolution with pre-examination pharmacist care in cancer outpatients, indicating proactive timing optimizes chemotherapy toxicity...

Key Points

To evaluate whether proactive pharmacist interventions conducted before oncology examinations improve symptom resolution and adverse event management compared to conventional post-examination interventions.
Retrospective comparative study at Nihon University Itabashi Hospital comparing proactive pre-examination interventions (June 2024–May 2025, N=188 patients, 303 interventions) with conventional post-examination interventions (June 2023–May 2024, N=164 patients, 227 interventions).
Assessed endpoints including the improvement rate (grade ≥ 2 adverse events improving to grade ≤ 1) and complete resolution rate (complete disappearance of adverse events of any baseline grade).
Overall adverse event improvement was significantly higher in the proactive group compared to the conventional group (80% vs. 69%, P = 0.034), as was the complete resolution rate (50% vs. 30%, P < 0.001).
For chemotherapy-induced nausea and vomiting, the proactive group achieved higher improvement (93% vs. 70%, P = 0.009) and complete resolution (48% vs. 23%, P = 0.002); non-emetic toxicities also demonstrated superior complete resolution (51% vs. 32%, P < 0.001) despite similar improvement rates (74% vs. 68%, P = 0.356).

Cite This Study

Washinosu et al. (2026) studied this question.

synapsesocial.com/papers/6a9299c88e5d7d1fc0c11ec8 https://doi.org/10.1186/s40780-026-00622-x

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Implication

Retrospective comparative study reveals higher adverse event resolution with pre-examination pharmacist care in cancer outpatients, indicating proactive timing optimizes chemotherapy toxicity...

Impact of interventions for adverse events by oncology pharmacists before versus after medical examination in outpatient chemotherapy: a retrospective, comparative study

Discussion

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Implication

Key Points

Cite This Study

Impact of interventions for adverse events by oncology pharmacists before versus after medical examination in outpatient chemotherapy: a retrospective, comparative study

Discussion

Member takes

Implication

Key Points

Cite This Study

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