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November 1, 1997AJP Heart and Circulatory Physiology

Cardiorenal epinephrine kinetics: evidence for neuronal release in the human heart

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Why the study?

Is there evidence for neuronal release of epinephrine in the human heart and kidney in patients with heart failure, hypertension, and healthy subjects?

Population

Patients with congestive heart failure, patients with hypertension, and healthy subjects

Comparison

Isotope-dilution method, intense supine… vs Baseline measurements

Design

Other

Authors

MJMats JohanssonMinistry of FinanceBRBengt RundqvistOslo University HospitalGEGraeme EisenhoferUniversity Hospital Carl Gustav Carus

Discussion

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Implication

Evidence of neuronal epinephrine release in human heart and kidney during exercise; hypothesis-generating for its role in heart failure and hypertension.

Structured PICO

Is there evidence for neuronal release of epinephrine in the human heart and kidney in patients with heart failure, hypertension, and healthy subjects?

P
Population
Patients with congestive heart failure, patients with hypertension, and healthy subjects
I
Intervention
Isotope-dilution method, intense supine exercise, and blockade of neuronal uptake 1
C
Comparator
Baseline measurements
O
Outcome
Cardiac and renal epinephrine (Epi) and norepinephrine (NE) spillover and fractional extractionssurrogate

The study provides physiological evidence for cardiac neuronal epinephrine release and its removal by neuronal uptake in both the heart and kidney.

Cite This Study

Johansson et al. (1997) studied this question.

synapsesocial.com/papers/6a929a3a71c7499eda1830dehttps://doi.org/10.1152/ajpheart.1997.273.5.h2178

Topics

Heart failureHFrEF treatmentHypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences in the Neuronal Removal of Circulating Epinephrine and Norepinephrine1990 · 41 citations
  2. 2Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.1990 · 1,158 citations
  3. 3Noradrenaline Release And Sympathetic Nervous System Activity1985 · 167 citations
  4. 4Attenuated Cardiac Sympathetic Responsiveness During Dynamic Exercise in Patients With Heart Failure1997 · 40 citations
  5. 5Effects of Aging on the Responsiveness of the Human Cardiac Sympathetic Nerves to Stressors1995 · 183 citations