Key result
123I-MIBG scintigraphy showed significantly lower initial heart-to-mediastinum uptake ratios in diabetic patients with symptomatic neuropathy compared to normal controls (1.90 vs 2.41, p<0.01).
Why the study?
Does 123I-metaiodobenzylguanidine (MIBG) scintigraphy identify cardiac sympathetic nerve dysfunction in diabetic patients?
Population
18 diabetic patients (with and without symptomatic neuropathy) and 11 normal controls (n=29)
Comparison
123I-metaiodobenzylguanidine (MIBG) scintigraphy vs Normal controls and diabetic patients without…
Design
Cross-sectional
Authors
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MIBG scintigraphy may identify cardiac sympathetic dysfunction in diabetic neuropathy; hypothesis-generating and should not change practice without prospective validation.
Observational (n=29)
Does 123I-metaiodobenzylguanidine (MIBG) scintigraphy identify cardiac sympathetic nerve dysfunction in diabetic patients?
Absolute Event Rate: 1.9% vs 2.41%
p-value: p=<0.01
123I-MIBG scintigraphy can effectively detect cardiac sympathetic nerve disturbance in diabetic patients with symptomatic neuropathy.
Miyanaga et al. (1995) conducted an observational in Diabetes (n=29). 123I-metaiodobenzylguanidine (MIBG) scintigraphy vs. Diabetic patients without neuropathy and normal controls was evaluated on Heart to mediastinum uptake ratio (initial image) (p=<0.01). 123I-MIBG scintigraphy showed significantly lower initial heart-to-mediastinum uptake ratios in diabetic patients with symptomatic neuropathy compared to normal controls (1.90 vs 2.41, p<0.01).
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