Key result
Abnormal clinical cardiovascular adrenergic function in T2D is paradoxically linked to higher MIBG H/M ratios.
Why the study?
To assess the agreement between clinical cardiovascular adrenergic function and cardiac adrenergic innervation in patients with type 2 diabetes.
Does clinical cardiovascular adrenergic function correlate with cardiac adrenergic innervation assessed by 123I-MIBG scintigraphy in patients with type 2 diabetes?
Comparison
Clinical cardiovascular adrenergic assessment vs 123I-MIBG scintigraphy
Design
Cross-sectional study
Authors
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Paradoxical MIBG elevation with abnormal adrenergic function may reflect hypersensitivity; hypothesis-generating and should not change practice pending validation.
Cross-Sectional (n=33)
Does clinical cardiovascular adrenergic function correlate with cardiac adrenergic innervation assessed by 123I-MIBG scintigraphy in patients with type 2 diabetes?
In patients with type 2 diabetes, there is a paradoxical inverted relationship between clinical cardiovascular adrenergic responses and 123I-MIBG scintigraphy indices, potentially indicating adrenergic hypersensitivity in denervated hearts.
Rasmussen et al. (2024) conducted a cross-sectional in Type 2 diabetes (n=33). 123I-MIBG scintigraphy and clinical cardiovascular adrenergic assessment was evaluated on Agreement between clinical cardiovascular adrenergic function and cardiac adrenergic innervation. In patients with type 2 diabetes, abnormal clinical cardiovascular adrenergic function was paradoxically associated with higher early (1.76 vs 1.57, p<0.001) and delayed H/M ratios on MIBG.
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