May 1, 1995Diabetes

Myocardial m-123IIodobenzylguanidine Scintigraphy for the Assessment of Adrenergic Cardiac Innervation in Patients With IDDM: Comparison With Cardiovascular Reflex Tests and Relationship to Left Ventricular Function

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Why the study?

Does mIBG scintigraphy detect sympathetic myocardial dysinnervation more frequently than cardiovascular reflex tests, and does it correlate with subclinical LV dysfunction in patients with IDDM?

Population

24 patients with insulin-dependent diabetes mellitus without overt heart disease and 10 control subjects.

Comparison

m-[123I]iodobenzylguanidine scintigraphy and… vs Cardiovascular reflex tests; and comparison…

Design

Cross-sectional

Authors

GKGerhard KreinerMedical University of Vienna MWMichael WolztVascular Medicine PFPeter FaschingUniversity of Vienna

Discussion

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Implication

mIBG may detect subclinical denervation and LV dysfunction missed by reflex tests in diabetes; leaves open its prognostic utility and role in management.

Structured PICO

Does mIBG scintigraphy detect sympathetic myocardial dysinnervation more frequently than cardiovascular reflex tests, and does it correlate with subclinical LV dysfunction in patients with IDDM?

Population

24 patients with insulin-dependent diabetes mellitus (IDDM) without overt heart disease (silent coronary artery disease excluded by 201Tl scintigraphy) and 10 control subjects (total n=34).

Intervention

m-[123I]iodobenzylguanidine (mIBG) scintigraphy (tomographic imaging) and equilibrium radionuclide angiography at rest and during bicycle exercise

Comparator

Cardiovascular reflex tests; and comparison between IDDM patients with normal vs. abnormal mIBG scans, as well as healthy controls

Outcome

Prevalence of derangements of cardiac autonomic innervation and the relationship between adrenergic cardiac innervation and left ventricular function (ejection fraction and peak filling rate)surrogate

mIBG scintigraphy reveals that sympathetic myocardial dysinnervation is highly prevalent in IDDM patients and correlates with subclinical left ventricular dysfunction.

Cite This Study

Kreiner et al. (1995) studied this question.

synapsesocial.com/papers/6a7a4c5be357fbdac589737a https://doi.org/10.2337/diab.44.5.543

Topics

Women and heart disease

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Implication

mIBG may detect subclinical denervation and LV dysfunction missed by reflex tests in diabetes; leaves open its prognostic utility and role in management.

Myocardial m-123IIodobenzylguanidine Scintigraphy for the Assessment of Adrenergic Cardiac Innervation in Patients With IDDM: Comparison With Cardiovascular Reflex Tests and Relationship to Left Ventricular Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Myocardial m-123IIodobenzylguanidine Scintigraphy for the Assessment of Adrenergic Cardiac Innervation in Patients With IDDM: Comparison With Cardiovascular Reflex Tests and Relationship to Left Ventricular Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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