Key result
GW3965 significantly blunted the vasopressor effect of Ang II at 0.3 and 3 microg/kg doses in male Sprague-Dawley rats, coincident with a trend toward reduced ATR gene expression.
Why the study?
Does GW3965 reduce angiotensin II-mediated pressor responses in male Sprague-Dawley rats?
Does GW3965 reduce angiotensin II-mediated pressor responses in male Sprague-Dawley rats?
The LXR agonist GW3965 decreases Ang II-mediated vasopressor responses and tends to reduce ATR gene expression in rats, suggesting a role in modulating vascular reactivity.
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Hypothesis-generating for LXR modulation of vascular reactivity; requires human studies before any clinical consideration.
Leik et al. (2007) studied Angiotensin II-mediated pressor responses. GW3965 vs. Vehicle was evaluated on Arterial blood pressure during Ang II infusions. GW3965 significantly blunted the vasopressor effect of Ang II at 0.3 and 3 microg/kg doses in male Sprague-Dawley rats, coincident with a trend toward reduced ATR gene expression.
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