April 1, 1989Journal of Electrophysiology
Defibrillation Energy Requirements Differ Between Anesthetic Agents
Key result
Fentanyl anesthesia significantly lowered the energy required for 50% defibrillation success (3.8 ± 2.3 J) compared to pentobarbital (6.9 ± 3.0 J, P < 0.01).
Why the study?
Does the choice of anesthetic agent affect the energy requirements for internal defibrillation in a canine model?
Population
Dogs (n=53)
Comparison
Fentanyl or enflurane anesthesia vs Pentobarbital anesthesia
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Anesthetic choice may alter experimental defibrillation thresholds; leaves open translation to human clinical practice.
Structured PICO
Does the choice of anesthetic agent affect the energy requirements for internal defibrillation in a canine model?
P
Population
53 dogs anesthetized with pentobarbital, fentanyl, or enflurane to evaluate the effect of anesthesia on internal defibrillation energy requirements.
I
Intervention
Fentanyl (25 μg/kg/hour) or enflurane (0.5%–1.5%) anesthesia
C
Comparator
Pentobarbital (30 mg/kg IV followed by 2–3 mg/kg/hr constant infusion) anesthesia
O
Outcome
Energy required for 50% success (E50) and 80% success (E80) in internal defibrillationsurrogate
Main Result
Absolute Event Rate: 3.8% vs 6.9%
p-value: p=< 0.01
Anesthetic agents significantly modify defibrillation energy requirements, with fentanyl requiring lower energy than pentobarbital in a canine model.
Cite This Study
Wang et al. (1989) studied Defibrillation energy requirements (n=53). Fentanyl vs. Pentobarbital and enflurane was evaluated on Energy required for 50% success (E50) in defibrillation (p=< 0.01). Fentanyl anesthesia significantly lowered the energy required for 50% defibrillation success (3.8 ± 2.3 J) compared to pentobarbital (6.9 ± 3.0 J, P < 0.01).