Key result
Addition of 2 mM Ca2+ to bovine cardiac troponin C induced a conformational change to a more compact structure, increasing the sedimentation coefficient from 1.87 S to 2.04 S.
Population
Bovine cardiac troponin C (TN-C) in solution
Comparison
Addition of 2 mM Ca2+ vs Absence of Ca2+
Design
Preclinical
Authors
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Extends Ca2+-dependent troponin C structural insights in bovine models; leaves open relevance to human cardiac function.
The addition of calcium induces a conformational change in bovine cardiac troponin C to a more compact structure without altering its molecular weight.
Byers et al. (1982) studied this question. Ca2+ vs. absence of Ca2+ was evaluated on Hydrodynamic properties (sedimentation coefficient, Stokes radius, intrinsic viscosity). Addition of 2 mM Ca2+ to bovine cardiac troponin C induced a conformational change to a more compact structure, increasing the sedimentation coefficient from 1.87 S to 2.04 S.
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