Key result
Poliovirus easily circulated among family members, resulting in viral excretion even in a previously vaccinated individual with neutralizing antibodies.
Case Report (n=4)
No
Poliovirus can easily circulate among family members, including those with neutralizing antibodies from previous vaccination.
May indicate household poliovirus transmission despite vaccination; hypothesis-generating and requires confirmation in larger studies.
We describe a case of abortive poliomyelitis due to poliovirus type 3 (PV3) in an unvaccinated woman and a subclinical poliovirus infection in her family during an epidemic in the Netherlands. The woman excreted the epidemic strain (PV3) for 7 weeks. Her two children received oral attenuated poliovirus vaccine and were subsequently found to excrete PV1 and PV2 vaccine strains in addition to the epidemic PV3 strain. Her husband, who had neutralizing antibodies to all three poliovirus types because of previous vaccination, initially excreted no virus; subsequently, however, the vaccine strain PV1 and the epidemic strain PV3 could be cultured from his feces. These observations demonstrate the ease with which poliovirus circulates among family members, including those with neutralizing antibodies.
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Kroon et al. (1995) conducted a case report in Poliomyelitis (n=4). Poliovirus infection was evaluated on Poliovirus excretion. Poliovirus easily circulated among family members, resulting in viral excretion even in a previously vaccinated individual with neutralizing antibodies.
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