Why the study?
Does E-IPV compared to OPV improve mucosal immunity and reduce viral shedding upon challenge in polio vaccinees?
Population
Vaccinees who received either oral polio vaccine (OPV) or enhanced-potency inactivated polio vaccine (E-IPV)
Comparison
Enhanced-potency inactivated polio vaccine (E-IPV) vs Oral polio vaccine (OPV)
Design
Cohort
Authors
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E-IPV linked to higher shedding than OPV; hypothesis-generating for mucosal differences and should not yet change polio schedules.
Does E-IPV compared to OPV improve mucosal immunity and reduce viral shedding upon challenge in polio vaccinees?
E-IPV is less effective than OPV in preventing and limiting intestinal infection upon challenge, despite inducing higher postvaccination serum antibody levels.
Onorato et al. (1991) studied this question.
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