Key result
Oral poliovirus type 1 vaccine administered to infants had estimated 50%, 10%, and 1% human infective doses of 72, 39, and 20 tissue culture infective doses, respectively.
Why the study?
What are the 50%, 10%, and 1% human infective doses of oral poliovirus type 1 vaccine in infants?
What are the 50%, 10%, and 1% human infective doses of oral poliovirus type 1 vaccine in infants?
The study determined the specific tissue culture infective doses required to achieve 50%, 10%, and 1% infection rates for oral poliovirus type 1 vaccine in infants.
Answers are grounded in this paper and cite their sources.
May refine OPV dosing in infants; leaves open prospective validation for current strains.
The 50, 10, and 1% human infective doses of poliovirus type 1 vaccine administered orally to 32 infants were estimated to be 72, 39, and 20 tissue culture infective doses, respectively.
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Minor et al. (1981) studied this question. Oral poliovirus type 1 vaccine administered to infants had estimated 50%, 10%, and 1% human infective doses of 72, 39, and 20 tissue culture infective doses, respectively.
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