Key result
Inoculation of tonsil and adenoid tissue from a healthy 2-year-old child without contact history produced experimental poliomyelitis in monkeys, demonstrating a healthy carrier state.
Case Report (n=1)
The study demonstrates that a healthy child without known contact can carry the poliomyelitis virus in tonsil and adenoid tissue, capable of infecting monkeys.
Suggests asymptomatic polio carriage in children; leaves open human transmission implications pending clinical validation.
Tonsil and adenoid tissue obtained from a healthy child 2 years old, without any history of contact, produced the experimental disease when inoculated into 2 animals, 2. One of the animals, Monkey 107, recovered with atrophy and contractures involving the right lower extremity. 3. The other animal sacrificed in the acute stages of the disease showed histologie evidence of poliomyelitis and the material from the cord of this monkey has produced the frank recognizable disease with paralysis in the third and fourth passages (Monkeys 391 and 409).
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Stefan Krämer (1935) conducted a case report in Healthy carrier of Poliomyelitis (n=1). Inoculation of tonsil and adenoid tissue was evaluated on Production of experimental poliomyelitis disease in inoculated animals. Inoculation of tonsil and adenoid tissue from a healthy 2-year-old child without contact history produced experimental poliomyelitis in monkeys, demonstrating a healthy carrier state.
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