Key result
Obese insulin-resistant rats exhibited prolonged QTc intervals, increased action potential duration, and defective L-type calcium current inactivation compared to lean controls.
Authors
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Does not support clinical practice changes; leaves open translation of rat repolarization defects to human obesity-related arrhythmia risk.
Lin et al. (2011) studied Obesity-induced insulin resistance and long QT. Obesity-induced insulin resistance (Obese Zucker rat model) vs. Age-matched lean Zucker rat (LZR) was evaluated on QTc interval, action potential duration, and L-type calcium current inactivation. Obese insulin-resistant rats exhibited prolonged QTc intervals, increased action potential duration, and defective L-type calcium current inactivation compared to lean controls.
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