Antimalarials: The aim of our work was to investigate the ability of nonpeptidic vinyl and allyl phosphonates to inhibit falcipain-2 (FP-2), the main cysteine protease of P. falciparum. Some of the compounds synthesized, such as the one shown, moderately inhibit FP-2 activity.
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Ettari et al. (2008) studied this question.
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