Key result
Maternal self-medication with benzydamine hydrochloride (3-mg lozenges) in the third trimester was associated with premature constriction of the fetal ductus arteriosus in 3 cases.
Why the study?
Does maternal benzydamine hydrochloride therapy cause premature constriction of the fetal ductus arteriosus in third-trimester pregnancies?
Case Report (n=3)
Does maternal benzydamine hydrochloride therapy cause premature constriction of the fetal ductus arteriosus in third-trimester pregnancies?
Maternal use of over-the-counter benzydamine hydrochloride in the third trimester can cause premature constriction of the fetal ductus arteriosus and should be avoided.
Answers are grounded in this paper and cite their sources.
Benzydamine lozenges may risk fetal ductus constriction; leaves open need for prospective studies before practice change.
We report 3 cases of prenatal diagnosis of premature constriction of the ductus arteriosus after maternal benzydamine hydrochloride therapy (3-mg lozenges) in third-trimester pregnancies. In each case, fetal echocardiography revealed a dilated, hypocontractile right ventricle with severe tricuspid regurgitation and constriction of the ductus arteriosus. Although the effect of indomethacin and other nonsteroidal anti-inflammatory drugs on prenatal ductal constriction is well known, readily available over-the-counter nonsteroidal anti-inflammatory drugs such as benzydamine can have an equally deleterious effect and are best avoided in the third trimester of pregnancy.
No takes yet. Share an insight, caveat, or question.
Krzeszowski et al. (2015) conducted a case report in Premature constriction of the fetal ductus arteriosus (n=3). Benzydamine hydrochloride was evaluated on Premature constriction of the ductus arteriosus and right ventricular changes. Maternal self-medication with benzydamine hydrochloride (3-mg lozenges) in the third trimester was associated with premature constriction of the fetal ductus arteriosus in 3 cases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: