Key result
Maternal self-administration of nimesulide at 39 weeks of gestation caused premature ductal constriction and fetal tachycardia within 24 hours in a single case.
Why the study?
Does maternal nimesulide use cause premature ductal constriction in a term fetus?
Population
A mother at 39 weeks of gestation (n=1)
Design
Case_report
Follow-up
< 24 hours
Authors
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May warrant avoiding nimesulide near term; leaves open generalizability beyond this single case.
Case Report (n=1)
Does maternal nimesulide use cause premature ductal constriction in a term fetus?
Maternal use of nimesulide at term can rapidly cause premature ductal constriction and fetal heart rate abnormalities.
Prefumo et al. (2008) conducted a case report in Premature ductal constriction (n=1). Nimesulide was evaluated on Premature ductal constriction. Maternal self-administration of nimesulide at 39 weeks of gestation caused premature ductal constriction and fetal tachycardia within 24 hours in a single case.
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