Key result
Maternal naproxen ingestion immediately prior to birth was associated with premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in a term neonate.
Population
A 3,790-g term neonate who developed persistent pulmonary hypertension after birth with a closed ductus…
Design
Case_report
Authors
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May prompt naproxen avoidance near term; hypothesis-generating for NSAID class effects on fetal ductus.
Case Report (n=1)
Maternal ingestion of naproxen near term can cause premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in the newborn, similar to indomethacin.
Talati et al. (2000) conducted a case report in Persistent pulmonary hypertension (n=1). Maternal naproxen sodium ingestion was evaluated on Persistent pulmonary hypertension with closed ductus arteriosus. Maternal naproxen ingestion immediately prior to birth was associated with premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in a term neonate.
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