Key result
Nimesulide exposure in high-risk pregnancies resulted in 88.6% (39 of 44) of women taking home a live baby, with reversible oligohydramnios occurring in 54% of cases.
Why the study?
Does nimesulide improve pregnancy outcomes and prevent preterm delivery in women at high risk of second trimester loss?
Population
44 women at high risk of second trimester loss and early preterm delivery
Design
Cohort
Follow-up
Until delivery
Authors
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Supports monitored nimesulide use in high-risk pregnancies; leaves open randomized confirmation of benefit.
Observational (n=44)
Does nimesulide improve pregnancy outcomes and prevent preterm delivery in women at high risk of second trimester loss?
Nimesulide appears to offer significant benefit in preventing preterm delivery in high-risk women without long-term fetal harm, provided there is intensive ultrasound monitoring for reversible oligohydramnios.
Sawdy et al. (2004) conducted an observational in high risk of second trimester loss and early preterm delivery (n=44). Nimesulide was evaluated on live baby. Nimesulide exposure in high-risk pregnancies resulted in 88.6% (39 of 44) of women taking home a live baby, with reversible oligohydramnios occurring in 54% of cases.
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