Key result
Systemic corticosteroids and oral anticoagulation completely resolved symptoms and significantly decreased the mitral bioprosthetic valve gradient in a patient with eosinophilia-induced thrombosis.
Case Report (n=1)
Eosinophilia is a rare but reversible cause of bioprosthetic valve thrombosis that can be successfully managed with corticosteroids and oral anticoagulation.
May warrant eosinophilia evaluation in unexplained bioprosthetic valve thrombosis; single case leaves open broader efficacy of corticosteroids plus anticoagulation.
A 31-year-old man with a mitral bioprosthetic valve presented with recent worsening of exertional dyspnoea 7 years after the mitral valve replacement. Evaluation revealed an increased gradient across the thickened mitral bioprosthetic valve leaflets. Marked eosinophilia was present and was considered as a putative cause for bioprosthetic valve thrombosis. The treatment with systemic corticosteroids and oral anticoagulation led to complete resolution of symptoms with significant decrease in mitral bioprosthetic valve gradient and leaflet thinning. The case is reported to highlight the fact that eosinophilia may cause reversible bioprosthetic valve thrombosis.
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Kothari et al. (2018) conducted a case report in Bioprosthetic valve thrombosis from eosinophilia (n=1). Systemic corticosteroids and oral anticoagulation was evaluated on Resolution of symptoms and decrease in mitral bioprosthetic valve gradient. Systemic corticosteroids and oral anticoagulation completely resolved symptoms and significantly decreased the mitral bioprosthetic valve gradient in a patient with eosinophilia-induced thrombosis.
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