Key result
Treatment of eosinophilia with steroids prevented further episodes of recurrent prosthetic heart valve thrombosis in a 17-year-old girl on limited follow-up.
Why the study?
Does steroid treatment for eosinophilia prevent recurrent prosthetic heart valve thrombosis in a patient with mechanical heart valves and eosinophilia?
Case Report (n=1)
Does steroid treatment for eosinophilia prevent recurrent prosthetic heart valve thrombosis in a patient with mechanical heart valves and eosinophilia?
Eosinophilia should be considered as a potential underlying cause in patients with recurrent prosthetic heart valve thrombosis despite adequate anticoagulation, as targeted treatment with steroids may prevent recurrence.
Hypothesis-generating for eosinophilia in recurrent PHVT; leaves open steroid efficacy in larger cohorts.
Prosthetic heart valve thrombosis (PHVT) is a major cause of morbidity and mortality in patients with mechanical heart valves. We present a case of recurrent PHVT associated with eosinophilia. A 17-year-old girl underwent aortic and mitral valve replacement for rheumatic heart disease. Over a period of 4 years, she had four episodes of PHVT despite oral anticoagulation with adequate INR. Her investigations revealed eosinophilia which was missed during the previous episodes. No further episodes of PHVT occurred after treatment of eosinophilia with steroids on limited follow-up.
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Rai et al. (2017) conducted a case report in Prosthetic heart valve thrombosis associated with eosinophilia (n=1). Steroids was evaluated on Recurrence of prosthetic heart valve thrombosis. Treatment of eosinophilia with steroids prevented further episodes of recurrent prosthetic heart valve thrombosis in a 17-year-old girl on limited follow-up.
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