Key result
Adipose tissue hypertrophy is associated with a 70% lower annual generation rate of new adipocytes compared to hyperplasia (P<0.001) and correlates with insulin sensitivity (P<0.0001).
Population
764 subjects with BMI 18-60 kg/m2 (subgroup of 35 subjects for in vivo adipocyte turnover measurement)
Design
Cross-sectional
Authors
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Adipose hypertrophy may mark impaired adipocyte renewal and insulin resistance; leaves open whether morphology drives metabolic outcomes.
Cross-Sectional (n=764)
Effect estimate: beta-coefficient 0.3
p-value: p=<0.0001
Adipose tissue morphology is linked to total adipocyte number and generation rate, and correlates with insulin sensitivity independently of body fat level.
Westermark et al. (2009) conducted a cross-sectional in Adipose tissue morphology (n=764). Adipose tissue morphology (hypertrophy vs hyperplasia) was evaluated on Correlation of adipose tissue morphology with insulin sensitivity (beta-coefficient 0.3, p=<0.0001). Adipose tissue hypertrophy is associated with a 70% lower annual generation rate of new adipocytes compared to hyperplasia (P<0.001) and correlates with insulin sensitivity (P<0.0001).
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