Population
N-glycosylation substitution mutants of the kidney potassium channel ROMK1 (Kir 1.1)
Design
Preclinical
Authors
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Challenges canonical ROMK1 topology model; leaves open confirmation in native mammalian systems and functional relevance.
The study proposes a major revision to the topology of the ROMK1 potassium channel, suggesting the pore signature sequence is completely extracellular and the COOH terminus forms additional membrane-spanning segments.
Schwalbe et al. (1997) studied this question.
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