Population
Insect cell line (Spodoptera frugiperda, Sf9) expressing ROMK1 (an inwardly rectifying K+ channel)
Comparison
Abolition of glycosylation via N117Q mutation or… vs Wild-type ROMK1 (glycosylated)
Design
Preclinical
Authors
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No direct clinical translation for ROMK-related disorders; leaves open glycosylation's role in native renal K+ channel function in vivo.
Carbohydrate occupancy at the N-glycosylation sequon stabilizes the open state of the ROMK1 potassium channel.
Schwalbe et al. (1995) studied this question.
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