Key result
Higher platelet distribution width was associated with an increased risk of isolated systolic hypertension in women, and isolated diastolic or systolic-diastolic hypertension in men.
Why the study?
The relationship between platelet distribution width and hypertension remains controversial, prompting investigation into associations between platelet distribution width and hypertension subtypes across sexes.
Is platelet distribution width associated with specific hypertension subtypes in males and females?
Observational (n=73,469)
Is platelet distribution width associated with specific hypertension subtypes in males and females?
Answers are grounded in this paper and cite their sources.
Platelet distribution width exhibits sex-specific associations with different hypertension subtypes, suggesting potential differences in underlying pathophysiological mechanisms.
The prevalence of hypertension has increased rapidly in recent years. Currently, increasing attention has been paid to the relationship between hypertension and platelet abnormalities. As a simple and available platelet parameter, platelet distribution width (PDW) can reflect platelet abnormalities and further reflect the risk of thrombotic diseases. However, the views on PDW and hypertension are controversial at present studies. Hence, we aimed to find the associations between PDW and hypertension subtypes in the present study. A total of 73,469 participants (44,665 males and 28,804 females) were enrolled. We found that PDW was a risk factor for isolated systolic hypertension (ISH), and the risk of ISH increased with PDW quartiles among women. In men, high PDW might be a risk factor for isolated diastolic hypertension and systolic-diastolic hypertension.
No takes yet. Share an insight, caveat, or question.
Li et al. (2020) conducted an observational in Hypertension subtypes (n=73,469). Platelet distribution width (PDW) was evaluated on Hypertension subtypes (isolated systolic, isolated diastolic, and systolic-diastolic hypertension). Higher platelet distribution width was associated with an increased risk of isolated systolic hypertension in women, and isolated diastolic or systolic-diastolic hypertension in men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: