Key result
Ethanol (1 g/kg) reversed the guanabenz-evoked decreases in blood pressure and plasma catecholamine levels in conscious spontaneously hypertensive rats.
Why the study?
Does ethanol attenuate the hypotensive effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats?
Population
Conscious unrestrained spontaneously hypertensive rats
Comparison
Ethanol (e.g., 1 g/kg) vs Baseline hypotensive responses to guanabenz…
Design
Preclinical
Authors
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Ethanol may blunt central antihypertensives in hypertensive models; leaves open clinical relevance in humans.
Does ethanol attenuate the hypotensive effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats?
Ethanol adversely interacts with centrally acting antihypertensive drugs like guanabenz by increasing central sympathetic tone, thereby reversing their hypotensive effects.
Abdel‐Rahman et al. (1992) studied Hypertension. Ethanol vs. Guanabenz alone was evaluated on Hypotensive responses and plasma catecholamine levels. Ethanol (1 g/kg) reversed the guanabenz-evoked decreases in blood pressure and plasma catecholamine levels in conscious spontaneously hypertensive rats.