Key result
The muscarinic cholinergic influence on L-type Ca2+ current decreases after birth in rabbit ventricular cells, likely due to a diminishing influence of an inhibitory G protein on adenylyl cyclase.
The muscarinic cholinergic influence on L-type Ca2+ currents decreases after birth in rabbit ventricular cells, likely due to a diminishing influence of an inhibitory G protein on adenylyl cyclase.
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Neonatal rabbit data should not inform pediatric practice; leaves open developmental G protein-adenylyl cyclase regulation of ventricular Ca2+ currents.
Osaka et al. (1993) studied this question. Carbachol vs. Control was evaluated on Muscarinic cholinergic modulation of L-type Ca2+ current (ICa). The muscarinic cholinergic influence on L-type Ca2+ current decreases after birth in rabbit ventricular cells, likely due to a diminishing influence of an inhibitory G protein on adenylyl cyclase.
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