Key result
Atrial natriuretic peptide differentially modulates voltage-dependent calcium channels in bovine glomerulosa cells, stimulating L-current while inhibiting T-current.
Population
Bovine glomerulosa cells
Design
Preclinical
Authors
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May implicate T-type channel inhibition in ANP-mediated aldosterone suppression; leaves open human relevance.
ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of calcium current through T-type channels.
McCarthy et al. (1990) studied this question. Atrial natriuretic peptide (ANP) was evaluated on Effect on T- and L-type calcium channels. Atrial natriuretic peptide differentially modulates voltage-dependent calcium channels in bovine glomerulosa cells, stimulating L-current while inhibiting T-current.
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