Key result
A family history of hyperlipidemia in seven-year-old children was associated with significantly increased levels of total cholesterol, LDL cholesterol, and LDL/HDL ratio compared to controls (p<0.001).
Why the study?
Does a family history of premature cardiovascular disease or hyperlipidemia identify 7-year-old children with elevated cholesterol levels?
Case-Control (n=295)
Does a family history of premature cardiovascular disease or hyperlipidemia identify 7-year-old children with elevated cholesterol levels?
p-value: p=<0.001
Screening 7-year-old children based on a family history of hyperlipidemia, but not premature cardiovascular disease alone, effectively identifies those with elevated atherogenic lipid profiles.
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Supports selective lipid screening in 7-year-olds with family hyperlipidemia history; leaves open long-term outcome benefits.
Larsson et al. (1992) conducted a case-control in Family history of myocardial infarction, angina pectoris, or hyperlipidemia (n=295). Family history of myocardial infarction, angina pectoris, or hyperlipidemia vs. Classmates without such family history was evaluated on Serum cholesterol fractions and triglycerides (p=<0.001). A family history of hyperlipidemia in seven-year-old children was associated with significantly increased levels of total cholesterol, LDL cholesterol, and LDL/HDL ratio compared to controls (p<0.001).
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