Key result
Lateral contractions of single living cardiomyocytes measured via AFM were related to internal calcium intensity rather than vertical beating power.
This study demonstrates the use of AFM cantilevers to quantitatively measure nanomechanical behaviors and drug-induced changes in single living cardiomyocytes.
AFM lateral contractions linked to calcium in animal cardiomyocytes; hypothesis-generating for nanomechanics, leaves open human translation.
Nanomechanical behaviors of single living cardiomyocytes are quantitatively observed using calculated torsions and deflections of an AFM cantilever. The lateral contractions are related to the calcium intensity within rather than the vertical beating power of the cardiomyocytes. Drug-induced nanomechanical changes of cardiomyocytes were further investigated by measuring lateral contractions in real time.
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Feng et al. (2011) studied Cardiomyocytes. Atomic force microscopy (AFM) cantilever measurement was evaluated on Nanomechanical behaviors (lateral contractions and vertical beating power). Lateral contractions of single living cardiomyocytes measured via AFM were related to internal calcium intensity rather than vertical beating power.
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