Key result
Benznidazole treatment in Trypanosoma cruzi-infected rabbits did not arrest myocarditis and resulted in a shortened survival time, with 38% of treated rabbits developing malignant lymphomas.
Why the study?
Does Benznidazole arrest Chagas' heart myocarditis or improve survival in T. cruzi-infected rabbits?
Population
Trypanosoma cruzi-infected rabbits (including BCG-immunized rabbits)
Comparison
Benznidazole administered in the chronic phase… vs Untreated T. cruzi-infected rabbits
Design
Preclinical
Follow-up
Up to 765 +/- 639 days
Authors
Loading...
May warrant caution with benznidazole in Chagas myocarditis; leaves open its efficacy and safety in humans.
Does Benznidazole arrest Chagas' heart myocarditis or improve survival in T. cruzi-infected rabbits?
Absolute Event Rate: 525% vs 765%
p-value: p=>0.5
In a rabbit model of Chagas' disease, Benznidazole failed to arrest myocarditis and was associated with severe adverse effects including shortened survival, immunosuppression, and lymphoma development.
Teixeira et al. (1990) studied Chagas' disease (Trypanosoma cruzi infection) (n=36). Benznidazole vs. Untreated T. cruzi-infected rabbits was evaluated on Survival time (days) (p=>0.5). Benznidazole treatment in Trypanosoma cruzi-infected rabbits did not arrest myocarditis and resulted in a shortened survival time, with 38% of treated rabbits developing malignant lymphomas.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: