Why the study?
Does benznidazole reduce T. cruzi antigens in heart interstitial dendritic cells and myocardial inflammation in T. cruzi-infected mice?
Population
Swiss mice weighing 15-20 g infected with Trypanosoma cruzi (Colombian strain or clone 21SF-C3)
Comparison
Benznidazole 100 mg/kg/day by gavage, 5 days per… vs Untreated infected mice
Design
Preclinical
Follow-up
150 or 200 days post-treatment
Authors
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Reduces myocardial antigens and inflammation in infected mice; leaves open translation to human Chagas disease.
Does benznidazole reduce T. cruzi antigens in heart interstitial dendritic cells and myocardial inflammation in T. cruzi-infected mice?
In a murine model of Chagas disease, benznidazole treatment reduces parasite antigens in heart interstitial dendritic cells, which correlates with a decrease in chronic myocarditis.
Portella et al. (2009) studied this question.
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